Congenital Diaphragmatic Hernia: Comparison of Animal Models and Relevance to the Human Situation | Zendy

Rhian B. van Loenhout | Zendy; Dick Tibboel | Zendy; Martin Post | Zendy; Richard Keijzer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Congenital Diaphragmatic Hernia: Comparison of Animal Models and Relevance to the Human Situation

Author(s) -

Rhian B. van Loenhout,

Dick Tibboel,

Martin Post,

Richard Keijzer

Publication year - 2009

Publication title -

neonatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.399

H-Index - 84

eISSN - 1661-7819

pISSN - 1661-7800

DOI - 10.1159/000209850

Subject(s) - congenital diaphragmatic hernia , pulmonary hypoplasia , medicine , etiology , pulmonary hypertension , diaphragmatic hernia , animal model , hypoplasia , diaphragmatic breathing , hernia , intensive care medicine , pathogenesis , clinical significance , pediatrics , surgery , pathology , biology , pregnancy , fetus , genetics , alternative medicine

Congenital diaphragmatic hernia (CDH) occurs in 1 in 3,000 newborns. Mortality and morbidity are due to the amount of pulmonary hypoplasia (PH), the response on artificial ventilation and the presence of therapy-resistant pulmonary hypertension. The pathogenesis and etiology of CDH and its associated anomalies are still largely unknown despite all research efforts over the past years. Several animal models have been proposed to study CDH. In this review we compare surgical, pharmacological and transgenic models, and discuss their strengths and limitations to study PH.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research