The Delta-Beta-Crossing-Over Site in the Fusion Gene of the Lepore-Boston Disease Might Be Localized in a Preferential Recombination Region | Zendy

Yahia Chebloune | Zendy; G Trabuchet | Zendy; Didier Poncet | Zendy; Michel CohenSolal | Zendy; Claudine Faure | Zendy; G. Verdier | Zendy; V. Nigon | Zendy

Open Access

The Delta-Beta-Crossing-Over Site in the Fusion Gene of the Lepore-Boston Disease Might Be Localized in a Preferential Recombination Region

Author(s) -

Yahia Chebloune,

G Trabuchet,

Didier Poncet,

Michel CohenSolal,

Claudine Faure,

G. Verdier,

V. Nigon

Publication year - 1983

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000206910

Subject(s) - recombination , beta (programming language) , gene , genetics , biology , microbiology and biotechnology , computer science , programming language

The delta-beta-fusion gene of heterozygous Lepore-Boston patient contains a large intervening sequence (IVS2) which could derive entirely from the beta-gene. This conclusion was obtained using a specific beta-IVS2 probe to analyse the physical map of the Lepore-Boston DNA which has shown the presence of a specific beta-AvaII site at the 5' end of the delta-beta-Lepore fusion gene. Thus, the crossing-over between delta- and beta-globin genes to explain the delta-beta-Lepore recombination could be localized between the delta-codon 87 and the 5' end of the beta-IVS2. The second protein-encoding region might represent a preferential recombination position in disorders associated with structurally abnormal globin chains resulting from fusion genes.

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