Hemoglobin Phenotype and Mean Erythrocyte Volume in Sicilian People
Author(s) -
Aurelio Maggio,
Fabio Gagliano,
S Siciliano
Publication year - 1984
Publication title -
acta haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 56
eISSN - 1421-9662
pISSN - 0001-5792
DOI - 10.1159/000206588
Subject(s) - sicilian , phenotype , hemoglobin , hemoglobin variants , medicine , hemoglobin s , clinical phenotype , biology , genetics , gene , philosophy , linguistics , disease , sickle cell anemia
AA 500 AS 37 AC 8 AD Los Angeles 8 AG Copenhagen 4 89.1 ± 4.7’ 85.9 ± 5.4 83.1 ± 7.3 86.0 ± 4.7 86.8 ± 7.3 2 13 3 3 1 1 AAvs. AS: t = 2.68, p < O.Ol; AA vs. AC: t = 2.80, p < O.Ol; AA vs. AD: t = 1.54, p > O.l; AA vs. AG: t 0.91, p > O.l. In their very interesting paper Sheehan and Fren-kel [1] showed that 26.5% of HbAC and 18.6% of HbAS black males had microcytosis. These data are consistent with the hypothesis that the frequency of microcytosis in their population is related to α-thal-assemia and ß-chain phenotype. We have evaluated erythrocyte size in nonanemic Sicilian males and found 37 HbAS, 8 HbAC, 8 HbAD Los Angeles, 4 HbAG Copenhagen among 10,683 subjects in a screening program [2].
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