Acute Leukaemia following High-Dose Chemoradiotherapy with Bone Marrow Rescue for Ovarian Teratoma | Zendy

Denis Guyotat | Zendy; B Coiffier | Zendy; Líllian Gonçalves Campos | Zendy; E Archimbaud | Zendy; D. Treille | Zendy; A. Ehrsam | Zendy; D Fière | Zendy

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Acute Leukaemia following High-Dose Chemoradiotherapy with Bone Marrow Rescue for Ovarian Teratoma

Author(s) -

Denis Guyotat,

B Coiffier,

Líllian Gonçalves Campos,

E Archimbaud,

D. Treille,

A. Ehrsam,

D Fière

Publication year - 1988

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000205598

Subject(s) - medicine , acute myelomonocytic leukemia , cyclophosphamide , chemotherapy , chemoradiotherapy , bone marrow , total body irradiation , radiation therapy , ovarian teratoma , teratoma , surgery

A case of acute leukaemia following intensive chemo- and radiotherapy for solid tumour is reported. A 15-year-old girl received four courses of chemotherapy with adriamycin, cyclophosphamide and cisplatinum after the surgical diagnosis of ovarian immature teratoma. An intensification treatment was performed with cyclophosphamide and total body irradiation, followed by marrow rescue. The diagnosis of myelomonocytic acute leukaemia was performed 8 months later. The patient died after a transient improvement following a treatment by hydroxyurea. The roles of the primary tumour, of the chemotherapy and of the marrow transplantation in the occurrence of leukaemia are discussed.

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