Urocortin II Induces Nitric Oxide Production Through cAMP and Ca<sup>2+</sup> Related Pathways in Endothelial Cells
Author(s) -
Elena Grossini,
Claudio Molinari,
David Mary,
Francesca Uberti,
Flavio Ribichini,
Philippe Primo Caimmi,
Giovanni Vacca
Publication year - 2009
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000204097
Subject(s) - wortmannin , enos , medicine , endocrinology , forskolin , adenylyl cyclase , urocortin , nitric oxide , protein kinase b , mapk/erk pathway , chemistry , p38 mitogen activated protein kinases , biology , receptor , nitric oxide synthase , kinase , signal transduction , microbiology and biotechnology
Urocortin II has previously been shown in anesthetized pigs to increase coronary blood flow through activation of the endothelial nitric oxide synthase (eNOS) pathway and involvement of the subtype 2 of corticotropin releasing factor receptors (CRFR2). However, little information has been available regarding the intracellular signalling through these receptors and leading to the release of nitric oxide (NO).
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