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In a previous work we demonstrated that, in dialyzed squid axons, an impairment of the Ca2+(i)-regulatory site affected the apparent affinities for external Na+ and Ca2+ in a way opposite to that predicted by the exiting (ping-pong) models for the exchangers. In the present work, we used model simulations and actual experiments where the Ca2+(i)-regulatory remained always saturated while [Ca2+](i) was either limiting or near saturating for the internal Ca2+ transport sites. Under these conditions, both the theoretical and experimental transport activation curves for external Na+ and Ca2+ were those expected from the current kinetic schemes. These observations have two important implications: on the one hand, they confirm the ping-pong translocation schemes for Na+/Ca2+ exchange. On the other, they call for caution in interpreting kinetic data in membrane transport systems possessing intracellular ionic and/or metabolic regulation.

cellular physiology and biochemistry

The Squid Axon Na&lt;sup&gt;+&lt;/sup&gt;/Ca&lt;sup&gt;2+&lt;/sup&gt; Exchanger Shows Ping Pong Kinetics only when the Ca&lt;sub&gt;i&lt;/sub&gt;-regulatory Site is Saturated