Open AccessTreatment of Established Peritoneal Fibrosis by Gene Transfer of Smad7 in a Rat Model of Peritoneal Dialysis
Author(s) -
Yanyan Sun,
Fengxin Zhu,
Xueqing Yu,
Jing Nie,
Fengxian Huang,
Xiaoyan Li,
Ning Luo,
Hui Y. Lan,
Yongtao Wang
Publication year - 2009
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000203362
Subject(s) - peritoneal dialysis , medicine , fibrosis , peritoneum , peritoneal cavity , western blot , pathology , surgery , gene , biology , biochemistry
It has been shown that blockade of TGF-beta1 signaling with Smad7 prevents experimental peritoneal fibrosis. The present study investigated whether Smad7 has a therapeutic effect on established peritoneal fibrosis associated with peritoneal dialysis (PD).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom