Relationship between the CAG Repeat Polymorphism in the Androgen Receptor Gene and Acne in the Han Ethnic Group | Zendy

Zhi Yang | Zendy; Haijing Yu | Zendy; Baowen Cheng | Zendy; Wenru Tang | Zendy; Yongli Dong | Zendy; Chunjie Xiao | Zendy; Li He | Zendy

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Relationship between the CAG Repeat Polymorphism in the Androgen Receptor Gene and Acne in the Han Ethnic Group

Author(s) -

Zhi Yang,

Haijing Yu,

Baowen Cheng,

Wenru Tang,

Yongli Dong,

Chunjie Xiao,

Li He

Publication year - 2009

Publication title -

dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.224

H-Index - 92

eISSN - 1421-9832

pISSN - 1018-8665

DOI - 10.1159/000202983

Subject(s) - acne , androgen receptor , biology , gene , genetics , polymerase chain reaction , polymorphism (computer science) , microbiology and biotechnology , medicine , genotype , prostate cancer , cancer

The modulatory domain of the human androgen receptor (AR) gene contains a polymorphic CAG repeat coding for a polyglutamine tract which is inversely correlated with transcriptional activity of the AR. Androgens acting through the AR play a crucial role in the pathogenesis of acne vulgaris. We therefore investigated the relationship between CAG repeat polymorphism in the AR gene and acne susceptibility.

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