Acute Renal Failure and Its Risk Factors in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis | Zendy

ChiChih Hung | Zendy; WanChun Liu | Zendy; MeiChuan Kuo | Zendy; ChihHung Lee | Zendy; ShangJyh Hwang | Zendy; HungChun Chen | Zendy

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Acute Renal Failure and Its Risk Factors in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Author(s) -

ChiChih Hung,

WanChun Liu,

MeiChuan Kuo,

ChihHung Lee,

ShangJyh Hwang,

HungChun Chen

Publication year - 2009

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000195632

Subject(s) - medicine , toxic epidermal necrolysis , gastroenterology , hypoalbuminemia , renal function , dialysis , dermatology , kidney disease , allopurinol

Skin lesion is the most frequent manifestation of adverse drug reactions. Drug-induced cutaneous hypersensitivity and drug-induced acute interstitial nephritis might share a similar mechanism involving drug-specific T cells. We thus investigated the renal outcome of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the most severe drug-induced cutaneous hypersensitivity, and hypothesize that skin detachment in SJS/TEN might be associated with acute renal failure (ARF).

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