Rhein Inhibits TNF-α-Induced Human Aortic Smooth Muscle Cell Proliferation via Mitochondrial-Dependent Apoptosis | Zendy

SookKyoung Heo | Zendy; HyunJeong Yun | Zendy; WonHwan Park | Zendy; SunDong Park | Zendy

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Rhein Inhibits TNF-α-Induced Human Aortic Smooth Muscle Cell Proliferation via Mitochondrial-Dependent Apoptosis

Author(s) -

SookKyoung Heo,

HyunJeong Yun,

WonHwan Park,

SunDong Park

Publication year - 2009

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000189798

Subject(s) - apoptosis , cytochrome c , mitochondrion , poly adp ribose polymerase , vascular smooth muscle , microbiology and biotechnology , depolarization , cytosol , annexin , caspase , mitochondrial apoptosis induced channel , biology , programmed cell death , cell growth , chemistry , endocrinology , biochemistry , polymerase , smooth muscle , enzyme , gene

Vascular smooth-muscle cell proliferation plays an important role in atherosclerosis and restenosis. Rhein is an active component extracted from rhubarb. In this study, rhein was found to exert potent inhibitory effects against tumor necrosis factor (TNF)-alpha-induced human aortic smooth-muscle cells (HASMCs) proliferation.

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