Pimecrolimus Reduces Eosinophil Activation Associated with Calcium Mobilization | Zendy

Douglas A. Plager | Zendy; Susan A. Henke | Zendy; Yoshinori Matsuwaki | Zendy; Arvind Madaan | Zendy; Diane L. Squillace | Zendy; Ross Dierkhising | Zendy; Hirohito Kita | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Pimecrolimus Reduces Eosinophil Activation Associated with Calcium Mobilization

Author(s) -

Douglas A. Plager,

Susan A. Henke,

Yoshinori Matsuwaki,

Arvind Madaan,

Diane L. Squillace,

Ross Dierkhising,

Hirohito Kita

Publication year - 2009

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000189194

Subject(s) - pimecrolimus , eosinophil , degranulation , calcineurin , immunology , superoxide , eosinophil cationic protein , chemistry , biology , medicine , transplantation , biochemistry , receptor , asthma , enzyme

Pimecrolimus is a calcineurin inhibitor that inhibits T cell and mast cell activation and effectively treats atopic dermatitis. However, its effects on eosinophils, a cell type implicated in allergic disease pathology, are unknown. Therefore, we examined the effects of pimecrolimus on eosinophil superoxide anion production, degranulation and survival.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research