The Synthesis of a Novel Chalcone and Evaluation for Anti-free Radical Activity and Antagonizing the Learning Impairments in Alzheimers Model | Zendy

Ying Pan | Zendy; Yicun Chen | Zendy; Xiaoyu Yu | Zendy; Jinzhi Wang | Zendy; Lumian Zhang | Zendy; Ying He | Zendy; Yu Zheng | Zendy; Jinhong Zheng | Zendy

Open Access

The Synthesis of a Novel Chalcone and Evaluation for Anti-free Radical Activity and Antagonizing the Learning Impairments in Alzheimers Model

Author(s) -

Ying Pan,

Yicun Chen,

Xiaoyu Yu,

Jinzhi Wang,

Lumian Zhang,

Ying He,

Yu Zheng,

Jinhong Zheng

Publication year - 2012

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000188336

Subject(s) - chalcone , chemistry , dpph , morris water navigation task , oxidative stress , glutathione peroxidase , glutathione , pharmacology , antioxidant , radical , biochemistry , alzheimer's disease , superoxide dismutase , hippocampus , stereochemistry , medicine , enzyme , disease

We synthesized a new chalcone (4,2'-dihydroxy-3methoxy-5-bromine chalcone; C) and structurally identified it via infrared spectrometry (IR), (1)H-NMR, mass spectrometry (MS) and element analysis (EA). C was confirmed to be highly potent in scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and OH free radicals in vitro. Tests of anti-free radical activity in response to oxidative stress in mice revealed that C could elevate glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lower malonaldehyde (MDA) level in a free-radical-injured scopolamine-induced Alzheimer's model. Further behavioral tests with the Morris water maze showed that C could antagonize the learning impairments in the Alzheimer's model, which suggests that C has a potential role in Alzheimer's disease.

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