Captopril and Transplant Renal Artery Stenosis

Dr. M.R. Ogborn, Izaak Walton Killam Hospital for Children, PO Box 3070, Halifax, N.S. B3J 3G9 (Canada) Dear Sir, The recent excellent review of posttransplantation hypertension by Waltzer et al. [1] suggests that deterioration of renal function with captopril therapy may be indicative of the severity of transplant artery stenosis. We report a case in which labile renal dysfunction was precipitated by the use of captopril, in the presence of a narrowing of the transplant artery that was of dubious functional significance. mm Hg) developed, which was controlled with metoprolol 25 mg b.i.d. Her renal function and hypertension control have now remained stable for 9 months after transplantation. Alpha methyl D0PA 250mg t.i.d. 1000-, -. 800 Captopril 50mg t.i.d Metoprolol 25mg b.i.d. ‚ 600 = – 500-S 400 =*■ 300H “ 200 100-