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We have studied urine flow rates (ml/min), urine osmolarity (mosm/1), and the urinary concentration (pg/ml) and excretion rates (ng/2 h) of prostaglandin E2 (PGE2) in 2 healthy subjects after an oral water load (1,000 ml) and during subsequent fluid deprivation for 11 h. Both with and without inhibition of endogenous prostaglandin synthesis with indomethacin (150 mg/day for 3 days) a rise in the concentration of urinary PGE2 was seen during anti-diuresis in parallel with urinary osmolarity (without indomethacin: r = 0.85, p < O.001; during indomethacin: r = 0.91, p < O.001 ;fig. 1A) and in reciprocity with urine flow rate (without indomethacin: r = -0,73, p < O.Ol; during indomethacin: r = -0.68, p < 0.01; fig. IB). No correlation was seen between urine flow rate and the excretion of PGE2 during antidiuresis.

Urine Osmolarity and the Excretion of Prostaglandin E2 in Man

Urine Osmolarity and the Excretion of Prostaglandin E₂ in Man