Lipoprotein-Associated Phospholipase A2 Activity and Risk of Recurrent Stroke | Zendy

Mitchell S.V. Elkind | Zendy; Wanling Tai | Zendy; Kristen Coates | Zendy; Myunghee Cho Paik | Zendy; Ralph L. Sacco | Zendy

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Lipoprotein-Associated Phospholipase A<sub>2</sub> Activity and Risk of Recurrent Stroke

Author(s) -

Mitchell S.V. Elkind,

Wanling Tai,

Kristen Coates,

Myunghee Cho Paik,

Ralph L. Sacco

Publication year - 2008

Publication title -

cerebrovascular diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.221

H-Index - 104

eISSN - 1421-9786

pISSN - 1015-9770

DOI - 10.1159/000172633

Subject(s) - medicine , quartile , hazard ratio , stroke (engine) , proportional hazards model , confidence interval , lipoprotein associated phospholipase a2 , population , lipoprotein(a) , gastroenterology , lipoprotein , cholesterol , mechanical engineering , environmental health , engineering

Mass levels of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a leukocyte-derived enzyme involved in the metabolism of low-density lipoprotein to pro-inflammatory mediators, are associated with prognosis after stroke. Lp-PLA(2) mass correlates only moderately with levels of Lp-PLA(2) activity. The relationship of Lp-PLA(2) activity to risk of stroke recurrence is unknown. We hypothesized that Lp-PLA(2) activity levels would predict risk of recurrence.

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