Open AccessDifferential Analgesic Effects of a Mu-Opioid Peptide, [Dmt<sup>1</sup>]DALDA, and Morphine
Author(s) -
Megumi Shimoyama,
Hazel H. Szeto,
Peter W. Schiller,
Yugo Tagaito,
Hideyuki Tokairin,
Chong moon Eun,
Naohito Shimoyama
Publication year - 2008
Publication title -
pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.51
H-Index - 59
eISSN - 1423-0313
pISSN - 0031-7012
DOI - 10.1159/000167878
Subject(s) - analgesic , morphine , (+) naloxone , tail flick test , pharmacology , opioid , chemistry , medicine , nociception , receptor , biochemistry
H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA), a highly selective micro-opioid peptide, is potently analgesic after systemic and intrathecal administration but is less potent given intracerebroventricularly. This study was performed to further characterize the analgesic effects of [Dmt(1)]DALDA.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom