The Difference in p53 Mutations between Cancers of the Upper and Lower Gastrointestinal Tract | Zendy

Eiji Oki | Zendy; Yan Zhao | Zendy; Rintaro Yoshida | Zendy; Akinori Egashira | Zendy; Kippei Ohgaki | Zendy; Masaru Morita | Zendy; Yoshihiro Kakeji | Zendy; Yoshihiko Maehara | Zendy

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The Difference in p53 Mutations between Cancers of the Upper and Lower Gastrointestinal Tract

Author(s) -

Eiji Oki,

Yan Zhao,

Rintaro Yoshida,

Akinori Egashira,

Kippei Ohgaki,

Masaru Morita,

Yoshihiro Kakeji,

Yoshihiko Maehara

Publication year - 2009

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000167864

Subject(s) - loss of heterozygosity , esophagus , stomach , carcinogenesis , biology , mutation , cancer , gastrointestinal tract , medicine , transversion , gastroenterology , cancer research , gene , genetics , allele

p53 gene mutations have been reported in over half of all human cancers and they appear to occur in the early stage of cancer, thus indicating the important role that such mutations may play in the carcinogenesis of the digestive tract. This study investigated the differences in p53 abnormalities between cancers of the upper and lower gastrointestinal tract.

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