Adiposity and Gastrointestinal Malignancy
Author(s) -
Joji Kitayama,
Masafumi Tabuchi,
Giichiro Tsurita,
Makoto Ishikawa,
Kensuke Otani,
Hirokazu Nagawa
Publication year - 2009
Publication title -
digestion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.882
H-Index - 75
eISSN - 1421-9867
pISSN - 0012-2823
DOI - 10.1159/000167863
Subject(s) - medicine , adiponectin , malignancy , cancer , gastrointestinal cancer , gastroenterology , hypertriglyceridemia , pathophysiology , metastasis , obesity , oncology , colorectal cancer , insulin resistance , triglyceride , cholesterol
Recent epidemiologic studies have shown a positive association between obesity and certain cancers. Our retrospective studies show that hypertriglyceridemia is an independent risk factor for the development of colonic adenoma and nodal metastasis in early gastric and esophageal cancer in men. High-fat condition may be favorable for the growth of malignant cells. Serum level of adiponectin is reduced in patients with advanced gastric cancer, which may be associated with the positive link between adiposity and cancer. In early gastric cancer, patients with undifferentiated type have lower fat volume than those with differentiated type. Adiposity appears to be closely related with various aspects in pathophysiology of gastrointestinal malignancy.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom