What Do We Mean by ‘Replication’ and ‘Validation’ in Genome-Wide Association Studies? | Zendy

BerndWolfgang Igl | Zendy; Inke R. König | Zendy; Andreas Ziegler | Zendy

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What Do We Mean by ‘Replication’ and ‘Validation’ in Genome-Wide Association Studies?

Author(s) -

BerndWolfgang Igl,

Inke R. König,

Andreas Ziegler

Publication year - 2008

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000164400

Subject(s) - replication (statistics) , confusion , meaning (existential) , computational biology , genome wide association study , genome , biology , association (psychology) , computer science , genetics , psychology , single nucleotide polymorphism , gene , genotype , virology , psychoanalysis , psychotherapist

It has been acknowledged that results from genome-wide association studies need to be reproduced in further independent samples. This includes both aspects of replication and validation. Although often used interchangeably, both of these terms have a specific unique meaning and are not synonyms. Based on a number of applications from the literature producing a certain amount of confusion, our aim therefore is to clarify the definition of 'replication' and 'validation' and propose standards of their usage.

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