Effect of Hypoxic-Ischemic Injury on Serine Palmitoyltransferase Activity in the Developing Rat Brain | Zendy

Masaki Daigo | Zendy; Yasuhiro Arai | Zendy; Kyoichi Oshida | Zendy; Yohei Kitamura | Zendy; Masaharu Hayashi | Zendy; Toshiaki Shimizu | Zendy; Yuichiro Yamashiro | Zendy

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Effect of Hypoxic-Ischemic Injury on Serine Palmitoyltransferase Activity in the Developing Rat Brain

Author(s) -

Masaki Daigo,

Yasuhiro Arai,

Kyoichi Oshida,

Yohei Kitamura,

Masaharu Hayashi,

Toshiaki Shimizu,

Yuichiro Yamashiro

Publication year - 2008

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000164217

Subject(s) - sphingolipid , serine , ceramide , biology , biochemistry , medicine , endocrinology , chemistry , enzyme , apoptosis

Sphingolipid metabolism is strongly associated with central nervous system myelination. Ceramide is the most active of the sphingolipid metabolites. On the basis of ceramide biosynthesis indicated by serine palmitoyltransferase activity and cerebroside generated by ceramide, the evaluation of serine palmitoyltransferase activity in developing brains or hypoxic-ischemic damaged brains is worthwhile.

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