Effect of the Polymorphism of Tumor Necrosis Factor-α-308 G/A Gene Promoter on the Susceptibility to Ulcerative Colitis: A Meta-Analysis | Zendy

Zonghai Lu | Zendy; Lei Chen | Zendy; Hui Li | Zendy; Yanjun Zhao | Zendy; Lin Lin | Zendy

Open Access

Effect of the Polymorphism of Tumor Necrosis Factor-α-308 G/A Gene Promoter on the Susceptibility to Ulcerative Colitis: A Meta-Analysis

Author(s) -

Zonghai Lu,

Lei Chen,

Hui Li,

Yanjun Zhao,

Lin Lin

Publication year - 2008

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000158605

Subject(s) - meta analysis , odds ratio , allele , ulcerative colitis , medicine , genotype , gastroenterology , proinflammatory cytokine , immunology , genetics , biology , gene , disease , inflammation

Ulcerative colitis (UC) is a complex polygenic disease in which gene-environment interactions are important. Some studies have reported that proinflammatory polymorphisms in tumor necrosis factor-alpha-308 (TNF-alpha-308) gene promoter (substitution G-->A, designated as TNF1 and TNF2) is associated with increased UC risk. However, the results of individual studies have been inconsistent.

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