Open AccessTranscriptional Down-Regulation of Thromboxane A<sub>2</sub> Receptor Expression via Activation of MAPK ERK1/2, p38/NF-κB Pathways
Author(s) -
Wei Zhang,
Yaping Zhang,
Lars Edvinsson,
CangBao Xu
Publication year - 2008
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000153247
Subject(s) - mapk/erk pathway , nf κb , microbiology and biotechnology , p38 mitogen activated protein kinases , thromboxane a2 , signal transduction , chemistry , receptor , biology , endocrinology , biochemistry
We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A(2) (TP) receptors was studied.
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