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Exercise training enhances vasodilatation to vascular endothelial growth factor (VEGF(165)) in collateral-dependent coronary arterioles. Interaction of VEGF receptor 2 (VEGFR-2) and the non-tyrosine-kinase receptor, neuropilin-1 has been reported to potentiate VEGF(165)-mediated signaling. In the current study, we tested the hypotheses that neuropilin-1 mediates the exercise-enhanced VEGF(165)-mediated vasodilatation in collateral-dependent arterioles and that neuropilin-1 and/or VEGFR-2 protein levels are increased in these arterioles.

journal of vascular research

Neuropilin-1 Is Essential for Enhanced VEGF&lt;sub&gt;165&lt;/sub&gt;-Mediated Vasodilatation in Collateral-Dependent Coronary Arterioles of Exercise-Trained Pigs