Neuropilin-1 Is Essential for Enhanced VEGF165-Mediated Vasodilatation in Collateral-Dependent Coronary Arterioles of Exercise-Trained Pigs | Zendy

Jennifer Fogarty | Zendy; Michael D. Delp | Zendy; Judy M. MullerDelp | Zendy; Glen A. Laine | Zendy; Janet L. Parker | Zendy; Cristine L. Heaps | Zendy

Open Access

Neuropilin-1 Is Essential for Enhanced VEGF<sub>165</sub>-Mediated Vasodilatation in Collateral-Dependent Coronary Arterioles of Exercise-Trained Pigs

Author(s) -

Jennifer Fogarty,

Michael D. Delp,

Judy M. MullerDelp,

Glen A. Laine,

Janet L. Parker,

Cristine L. Heaps

Publication year - 2008

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000152351

Subject(s) - vasodilation , neuropilin 1 , medicine , endocrinology , neuropilin , vascular endothelial growth factor , vegf receptors

Exercise training enhances vasodilatation to vascular endothelial growth factor (VEGF(165)) in collateral-dependent coronary arterioles. Interaction of VEGF receptor 2 (VEGFR-2) and the non-tyrosine-kinase receptor, neuropilin-1 has been reported to potentiate VEGF(165)-mediated signaling. In the current study, we tested the hypotheses that neuropilin-1 mediates the exercise-enhanced VEGF(165)-mediated vasodilatation in collateral-dependent arterioles and that neuropilin-1 and/or VEGFR-2 protein levels are increased in these arterioles.

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