Losses of Chromosome Arms 4q, 8p, 13q and Gain of 8q Are Correlated with Increasing Chromosomal Instability in Hepatocellular Carcinoma | Zendy

Sabine Hertz | Zendy; Thomas Rothämel | Zendy; Britta Skawran | Zendy; Christian Giere | Zendy; Doris Steinemann | Zendy; Peer Flemming | Zendy; Thomas Becker | Zendy; Jacobus Flik | Zendy; Birgit Wiese | Zendy; B. Soudah | Zendy; Hans Kreipe | Zendy; Brigitte Schlegelberger | Zendy; Ludwig Wilkens | Zendy

Open Access

Losses of Chromosome Arms 4q, 8p, 13q and Gain of 8q Are Correlated with Increasing Chromosomal Instability in Hepatocellular Carcinoma

Author(s) -

Sabine Hertz,

Thomas Rothämel,

Britta Skawran,

Christian Giere,

Doris Steinemann,

Peer Flemming,

Thomas Becker,

Jacobus Flik,

Birgit Wiese,

B. Soudah,

Hans Kreipe,

Brigitte Schlegelberger,

Ludwig Wilkens

Publication year - 2008

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000151712

Subject(s) - comparative genomic hybridization , fluorescence in situ hybridization , chromosome instability , hepatocellular carcinoma , biology , chromosome , genome instability , fish <actinopterygii> , microbiology and biotechnology , pathology , genetics , gene , medicine , dna , dna damage , fishery

Chromosomal instability is a key feature in hepatocellular carcinoma (HCC). Array comparative genomic hybridization (aCGH) revealed recurring structural aberrations, whereas fluorescence in situ hybridization (FISH) indicated an increasing number of numerical aberrations in dedifferentiating HCC. Therefore, we examined whether there was a correlation between structural and numerical aberrations of chromosomal instability in HCC.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research