MBD2-Mediated Transcriptional Repression of the p14ARF Tumor Suppressor Gene in Human Colon Cancer Cells | Zendy

Valérie Martin | Zendy; Helle F. Jørgensen | Zendy; Audrey S. Baur Chaubert | Zendy; Jennifer Berger | Zendy; Helen Barr | Zendy; Phillip Shaw | Zendy; Adrian Bird | Zendy; Pascal Chaubert | Zendy

Open Access

MBD2-Mediated Transcriptional Repression of the <i>p14</i><sup>ARF</sup> Tumor Suppressor Gene in Human Colon Cancer Cells

Author(s) -

Valérie Martin,

Helle F. Jørgensen,

Audrey S. Baur Chaubert,

Jennifer Berger,

Helen Barr,

Phillip Shaw,

Adrian Bird,

Pascal Chaubert

Publication year - 2008

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000151708

Subject(s) - dna methylation , microbiology and biotechnology , methylation , promoter , carcinogenesis , gene silencing , psychological repression , biology , gene , gene expression , genetics

The p14(ARF) and p16(INK4A) tumor suppressor genes are commonly inactivated by aberrant methylation of their promoter regions in human colon cancer. The methyl-CpG-binding domain protein MBD2 is physically associated with the methylated promoters of the p14(ARF) and p16(INK4A) genes in specific tumor cell lines. Moreover, deficiency of MBD2 strongly inhibits intestinal tumorigenesis in the Min mouse, raising the possibility that the protein might be involved in transcriptional repression of methylated tumor suppressor genes. The aim of this study was to evaluate the role of MBD2 in the silencing of p14(ARF) and p16(INK4A) in cancer.

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