The Human G147D-Protein Phosphatase 1 Inhibitor-1 Polymorphism Is Not Associated with Altered Clinical Characteristics in Heart Failure | Zendy

Guoli Chen | Zendy; Xiaoyang Zhou | Zendy; Anand Pathak | Zendy; Gerald W. Dorn | Zendy; Evangelia G. Kranias | Zendy

Open Access

The Human G147D-Protein Phosphatase 1 Inhibitor-1 Polymorphism Is Not Associated with Altered Clinical Characteristics in Heart Failure

Author(s) -

Guoli Chen,

Xiaoyang Zhou,

Anand Pathak,

Gerald W. Dorn,

Evangelia G. Kranias

Publication year - 2008

Publication title -

cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 63

eISSN - 1421-9751

pISSN - 0008-6312

DOI - 10.1159/000151240

Subject(s) - heart failure , genotype , medicine , polymorphism (computer science) , endocrinology , cardiology , biology , genetics , gene

A human protein phosphatase inhibitor-1 polymorphism, G147D (c.440G>A, p.147G>D), has been previously demonstrated to blunt the contractile responses of cardiomyocytes to beta-adrenergic agonists. The present study sought to examine whether the G147D inhibitor-1 polymorphism may be associated with specific clinical characteristics of heart failure carriers.

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