DNA Quantification and Fragmentation in Sputum after Inhalation of Recombinant Human Deoxyribonuclease | Zendy

J. Riethmueller | Zendy; Reinhard Vonthein | Zendy; Thomas BorthBruhns | Zendy; Heike Grassm eacute | Zendy; Matthias Eyrich | Zendy; Karin Schilbach | Zendy; Martin Stern | Zendy; Erich Gulbins | Zendy

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DNA Quantification and Fragmentation in Sputum after Inhalation of Recombinant Human Deoxyribonuclease

Author(s) -

J. Riethmueller,

Reinhard Vonthein,

Thomas BorthBruhns,

Heike Grassm eacute,

Matthias Eyrich,

Karin Schilbach,

Martin Stern,

Erich Gulbins

Publication year - 2008

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000149813

Subject(s) - sputum , agarose gel electrophoresis , dna , deoxyribonuclease , microbiology and biotechnology , cystic fibrosis , dna fragmentation , mucociliary clearance , pseudomonas aeruginosa , chemistry , biology , medicine , pathology , lung , biochemistry , bacteria , genetics , tuberculosis , apoptosis , programmed cell death

Inhaled rhDNase may improve sputum viscosity and mucociliary clearance by cleavage of extracellular DNA derived for instance from dead leukocytes in purulent, highly viscous patient sputum.

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