Caveolin and Proteasome in Tocotrienol Mediated Myocardial Protection | Zendy

Manika Das | Zendy; Samarjit Das | Zendy; Ping Wang | Zendy; Saul R. Powell | Zendy; Dipak K. Das | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Caveolin and Proteasome in Tocotrienol Mediated Myocardial Protection

Author(s) -

Manika Das,

Samarjit Das,

Ping Wang,

Saul R. Powell,

Dipak K. Das

Publication year - 2008

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000149807

Subject(s) - cardioprotection , proteasome , pharmacology , apoptosis , caveolin 1 , chemistry , mechanism (biology) , kinase , caveolin 3 , ischemia , medicine , biology , signal transduction , biochemistry , caveolae , philosophy , epistemology

The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research