Celecoxib Inhibits Serum Amyloid A-Induced Matrix Metalloproteinase-10 Expression in Human Endothelial Cells | Zendy

Yulan Zhao | Zendy; Shuli Zhou | Zendy; ChewKiat Heng | Zendy

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Celecoxib Inhibits Serum Amyloid A-Induced Matrix Metalloproteinase-10 Expression in Human Endothelial Cells

Author(s) -

Yulan Zhao,

Shuli Zhou,

ChewKiat Heng

Publication year - 2008

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000139134

Subject(s) - matrix metalloproteinase , celecoxib , serum amyloid a , endocrinology , chemistry , cyclooxygenase , medicine , prostaglandin e , microbiology and biotechnology , biology , inflammation , biochemistry , enzyme

Although serum amyloid A (SAA) is an established biomarker of coronary artery disease (CAD), its direct role in matrix degradation is obscure. This study investigated the effect of SAA on the expression of matrix metalloproteinase-10 (MMP-10) in endothelial cells. The effect of celecoxib on SAA-dependent MMP-10 expression and its possible mediator were also investigated.

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