Expression of RUNX3 Gene, Methylation Status and Clinicopathological Significance in Breast Cancer and Breast Cancer Cell Lines | Zendy

Ying Jiang | Zendy; Dandan Tong | Zendy; Ge Lou | Zendy; Ying Zhang | Zendy; Jingshu Geng | Zendy

Open Access

Expression of RUNX3 Gene, Methylation Status and Clinicopathological Significance in Breast Cancer and Breast Cancer Cell Lines

Author(s) -

Ying Jiang,

Dandan Tong,

Ge Lou,

Ying Zhang,

Jingshu Geng

Publication year - 2008

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000132385

Subject(s) - skbr3 , breast cancer , carcinogenesis , dna methylation , methylation , cancer research , immunohistochemistry , bisulfite sequencing , biology , cancer , tumor suppressor gene , western blot , microbiology and biotechnology , pathology , gene expression , medicine , gene , immunology , genetics , human breast

Runt-related transcription factor 3 (RUNX3) is a novel tumor suppressor gene that is frequently silenced by promoter hypermethylation in gastric cancer. In this study, we aimed to analyze the methylation status of the RUNX3 promoter in breast cancer and to evaluate the relationship between RUNX3 expression and breast carcinogenesis and prognosis.

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