Expression of the Counter-Regulatory Peptide Intermedin is Augmented in the Presence of Oxidative Stress in Hypertrophied Cardiomyocytes | Zendy

David Bell | Zendy; Youyou Zhao | Zendy; Francis McCoy | Zendy; Adrian Devine | Zendy; Barbara J. McDermott | Zendy

Open Access

Expression of the Counter-Regulatory Peptide Intermedin is Augmented in the Presence of Oxidative Stress in Hypertrophied Cardiomyocytes

Author(s) -

David Bell,

Youyou Zhao,

Francis McCoy,

Adrian Devine,

Barbara J. McDermott

Publication year - 2008

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000129633

Subject(s) - adrenomedullin , medicine , endocrinology , ventricle , oxidative stress , receptor , muscle hypertrophy , myocyte , chemistry , downregulation and upregulation , calcitonin gene related peptide , biochemistry , neuropeptide , gene

Intermedin (IMD), a novel cardiac peptide related to adrenomedullin (AM), protects against myocardial ischemia-reperfusion injury and attenuates ventricular remodelling. IMD's actions are mediated by a calcitonin receptor-like receptor in association with receptor activity modifying proteins (RAMPs 1-3).

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