Immune Modulation by Mesenchymal Stem Cells | Zendy

Francesco Bifari | Zendy; Veronica Lisi | Zendy; Elda Mimiola | Zendy; Annalisa Pasini | Zendy; Mauro Krampera | Zendy

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Immune Modulation by Mesenchymal Stem Cells

Author(s) -

Francesco Bifari,

Veronica Lisi,

Elda Mimiola,

Annalisa Pasini,

Mauro Krampera

Publication year - 2008

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000128968

Subject(s) - mesenchymal stem cell , immune system , stem cell , immune modulation , clinical uses of mesenchymal stem cells , immunology , stromal cell , immunotherapy , cancer research , cell therapy , in vivo , biology , medicine , microbiology and biotechnology , adult stem cell , in vitro , endothelial stem cell , biochemistry

SUMMARY: Mesenchymal stem cells (MSCs) and their stromal progeny may be considered powerful regulatory cells, a sort of dendritic cell counterpart, which influence all the main immune effectors and functional roles in vivo, as well as potential applications in the treatment of a number of human immunological diseases. By choosing MSC tissue origin, cell dose, administration route, and treatment schedule, all the potential side effects related to MSC use, including tumor growth enhancement, have to be well considered to maximize the benefits of MSC-depen-dent immune regulation without significant risks for the patients.

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