Altered Transforming Growth Factor-Beta Signaling in a Murine Model of Thoracic Aortic Aneurysm | Zendy

Jeffrey A. Jones | Zendy; John R. Barbour | Zendy; Robert E. Stroud | Zendy; Shenikqua Bouges | Zendy; Shelly L. Stephens | Zendy; Francis G. Spinale | Zendy; John S. Ikonomidis | Zendy

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Altered Transforming Growth Factor-Beta Signaling in a Murine Model of Thoracic Aortic Aneurysm

Author(s) -

Jeffrey A. Jones,

John R. Barbour,

Robert E. Stroud,

Shenikqua Bouges,

Shelly L. Stephens,

Francis G. Spinale,

John S. Ikonomidis

Publication year - 2008

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000127437

Subject(s) - transforming growth factor , signal transduction , transforming growth factor beta , receptor , thoracic aortic aneurysm , biology , endoglin , extracellular , r smad , medicine , endocrinology , chemistry , aortic aneurysm , microbiology and biotechnology , growth factor , aorta , tgf alpha , biochemistry , stem cell , cd34

Thoracic aortic aneurysms (TAAs) develop by a multifactorial process involving maladaptive signaling pathways that alter the aortic vascular environment. Transforming growth factor-beta (TGF-beta) has been implicated in regulating the structure and composition of the extracellular matrix by differential activation of various intracellular signaling pathways. However, whether and to what degree TGF-beta signaling contributes to TAA development remains unclear. Accordingly, the hypothesis that alterations in TGF-beta signaling occur during aneurysm formation was tested in a murine model of TAA.

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