In vitro Differentiation Potential of Mesenchymal Stem Cells | Zendy

Jeffrey M. Gimble | Zendy; Farshid Guilak | Zendy; Mark Nuttall | Zendy; Solomon Sathishkumar | Zendy; Martin A. Vidal | Zendy; Bruce A. Bunnell | Zendy

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In vitro Differentiation Potential of Mesenchymal Stem Cells

Author(s) -

Jeffrey M. Gimble,

Farshid Guilak,

Mark Nuttall,

Solomon Sathishkumar,

Martin A. Vidal,

Bruce A. Bunnell

Publication year - 2008

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000124281

Subject(s) - mesenchymal stem cell , microbiology and biotechnology , stem cell transplantation for articular cartilage repair , biology , clinical uses of mesenchymal stem cells , progenitor cell , adipose tissue , bone marrow , stem cell , context (archaeology) , multipotent stem cell , adult stem cell , immunology , endothelial stem cell , in vitro , endocrinology , paleontology , biochemistry

SUMMARY: Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

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