Bilateral Thalamic Metastases in Endometrial Adenocarcinoma

pulmonary embolism 17 months after the diagnosis of brain metastases. Metastases confined to the thalami have seldom been reported [1] , and bilateral localization of endometrial adenocarcinoma is exceptional. A 61-year-old woman presented with dysesthesia of the face and upper limbs, memory impairment and apathy. T 1 -weighted MRI showed mass lesions in both thalami ( fig. 1 ). Her medical history included a stage IIB grade III endometrial cancer treated with surgery and radiotherapy 1 year earlier. Whole-body search for metastases was negative. Stereotactic biopsies confirmed the metastatic nature of the thalamic lesions ( fig. 2 ). Radiotherapy resulted in improvement of the neurological and imaging conditions, but the patient died from Published online: April 11, 2008