Mouse Models of Experimental Autoimmune Uveitis | Zendy

Rachel R. Caspi | Zendy; Phyllis B. Silver | Zendy; Dror Luger | Zendy; Jun Tang | Zendy; Lizette M. Cortes | Zendy; Giuseppina Pennesi | Zendy; Mary J. Mattapallil | Zendy; ChiChao Chan | Zendy

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Mouse Models of Experimental Autoimmune Uveitis

Author(s) -

Rachel R. Caspi,

Phyllis B. Silver,

Dror Luger,

Jun Tang,

Lizette M. Cortes,

Giuseppina Pennesi,

Mary J. Mattapallil,

ChiChao Chan

Publication year - 2008

Publication title -

ophthalmic research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 54

eISSN - 1423-0259

pISSN - 0030-3747

DOI - 10.1159/000119871

Subject(s) - uveitis , immunology , autoimmunity , pathogenesis , autoimmune disease , biology , medicine , neuroscience , immune system , antibody

The mouse model of experimental autoimmune uveitis, induced by immunization of mice with the retinal protein IRBP, was developed in our laboratory 20 years ago and published in 1988. Since that time it has been adopted by many investigators and has given rise to many studies that helped elucidate genetic influences, dissect the basic mechanisms of pathogenesis and test novel immunotherapeutic paradigms. The current overview will summarize the salient features of the experimental autoimmune uveitis model and discuss its mechanisms.

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