Thrombospondin 1 and Its Mimetic Peptide ABT-510 Decrease Angiogenesis and Inflammation in a Murine Model of Inflammatory Bowel Disease | Zendy

Salman R. Punekar | Zendy; Samantha Zak | Zendy; Valerie G. Kalter | Zendy; Larissa Dobransky | Zendy; Imran Punekar | Zendy; Jack Lawler | Zendy; Linda S. Gutierrez | Zendy

Open Access

Thrombospondin 1 and Its Mimetic Peptide ABT-510 Decrease Angiogenesis and Inflammation in a Murine Model of Inflammatory Bowel Disease

Author(s) -

Salman R. Punekar,

Samantha Zak,

Valerie G. Kalter,

Larissa Dobransky,

Imran Punekar,

Jack Lawler,

Linda S. Gutierrez

Publication year - 2008

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000113790

Subject(s) - inflammatory bowel disease , inflammation , myeloperoxidase , angiogenesis , cd31 , azoxymethane , colitis , medicine , neovascularization , in vivo , tumor necrosis factor alpha , endocrinology , immunology , chemistry , colorectal cancer , biology , cancer , disease , microbiology and biotechnology

Vascular abnormalities and expression of proangiogenic factors have been repeatedly reported in inflammatory bowel disease (IBD). Thrombospondin 1 (TSP-1) is a protein well known for its antiangiogenic and anti-inflammatory properties. Using the dextran sulfate sodium (DSS) model, the role of TSP-1 in IBD has been investigated in vivo.

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