Open AccessLeucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies
Author(s) -
George Perry,
Xiongwei Zhu,
Asim K. Babar,
Sandra L. Siedlak,
Qiwei Yang,
Genta Ito,
Takeshi Iwatsubo,
Mark A. Smith,
Shu G. Chen
Publication year - 2008
Publication title -
neurodegenerative diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.98
H-Index - 57
eISSN - 1660-2862
pISSN - 1660-2854
DOI - 10.1159/000113708
Subject(s) - lrrk2 , progressive supranuclear palsy , dementia with lewy bodies , lewy body , parkinson's disease , dementia , pathology , tau protein , alpha synuclein , neuroscience , alzheimer's disease , disease , biology , medicine
Mutations in leucine-rich repeat kinase 2 (LRRK2) are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease.
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