Mitochondrial Localization of Human Recombinant Adenovirus: From Evolution to Gene Therapy | Zendy

Salvatore Alesci | Zendy; Mones AbuAsab | Zendy; Shiromi M. Perera | Zendy; Maria Tsokos | Zendy; John C. Morris | Zendy; Karel Pacák | Zendy

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Mitochondrial Localization of Human Recombinant Adenovirus: From Evolution to Gene Therapy

Author(s) -

Salvatore Alesci,

Mones AbuAsab,

Shiromi M. Perera,

Maria Tsokos,

John C. Morris,

Karel Pacák

Publication year - 2007

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000113065

Subject(s) - genetic enhancement , recombinant dna , biology , mitochondrion , virology , mitochondrial dna , gene , pathogenesis , neuroscience , computational biology , immunology , microbiology and biotechnology , genetics

Mitochondrial research has influenced concepts in anthropology, human physiology and pathophysiology. We present here direct evidence that human recombinant viruses can localize in mitochondria to disrupt their integrity. This finding, while opening new perspectives in viral gene therapy, may provide new insights into the pathogenesis, prevention and treatment of viral diseases. In addition, it may advance the current understanding of cell evolution.

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