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plays a key role in modulating ascending nociceptive pathways and pain processing [5, 6] . Inhibitory postsynaptic transmission in the spinal cord involves mainly glycine and, to a lesser extent, GABA [7] . Apparently, positive glycine receptor modulation is not directly linked to the hypnotic effects of different anaesthetics. These findings and the studies of other groups point towards the strychnine-sensitive glycine receptor family as a target site for therapeutic agents aiming at inhibiting pain sensitization but not for inducing hypnosis [1, 4, 6] .

Strychnine-Sensitive Glycine Receptors Mediate the Analgesic but Not the Hypnotic Effects of Emulsified Volatile Anaesthetics