Strychnine-Sensitive Glycine Receptors Mediate the Analgesic but Not the Hypnotic Effects of Emulsified Volatile Anaesthetics | Zendy

Jörg Ahrens | Zendy; M. Leuwer | Zendy; Gertrud Haeseler | Zendy

Open Access

Strychnine-Sensitive Glycine Receptors Mediate the Analgesic but Not the Hypnotic Effects of Emulsified Volatile Anaesthetics

Author(s) -

Jörg Ahrens,

M. Leuwer,

Gertrud Haeseler

Publication year - 2008

Publication title -

pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.51

H-Index - 59

eISSN - 1423-0313

pISSN - 0031-7012

DOI - 10.1159/000112943

Subject(s) - strychnine , analgesic , glycine receptor , pharmacology , hypnotic , anesthesia , gabaa receptor , glycine , chemistry , receptor , medicine , biochemistry , amino acid

plays a key role in modulating ascending nociceptive pathways and pain processing [5, 6] . Inhibitory postsynaptic transmission in the spinal cord involves mainly glycine and, to a lesser extent, GABA [7] . Apparently, positive glycine receptor modulation is not directly linked to the hypnotic effects of different anaesthetics. These findings and the studies of other groups point towards the strychnine-sensitive glycine receptor family as a target site for therapeutic agents aiming at inhibiting pain sensitization but not for inducing hypnosis [1, 4, 6] .

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