New Insights into Growth Hormone Receptor Function and Clinical Implications | Zendy

Agnieszka M Lichanska | Zendy; Michael J. Waters | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

New Insights into Growth Hormone Receptor Function and Clinical Implications

Author(s) -

Agnieszka M Lichanska,

Michael J. Waters

Publication year - 2008

Publication title -

hormone research in paediatrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.816

H-Index - 89

eISSN - 1663-2826

pISSN - 1663-2818

DOI - 10.1159/000112586

Subject(s) - growth hormone , mechanism (biology) , receptor , growth hormone receptor , hormone , biology , function (biology) , short stature , hormone receptor , bioinformatics , endocrinology , computational biology , microbiology and biotechnology , genetics , cancer , philosophy , epistemology , breast cancer

Although used as a therapeutic for 50 years, it is only recently that the application of molecular techniques has provided a basis for understanding growth hormone's (GH) clinical actions. This article reviews progress in our current knowledge of the molecular mechanism of growth hormone (GH) receptor activation based on a number of physicochemical techniques, and documents insights gained into the means used by the activated GH receptor to control the expression of genes regulating growth and metabolism. These findings are related to disorders of short stature, and the therapeutic consequences are summarized.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research