NMDA Receptor Subunit NR2b: Effects on LH Release and GnRH Gene Expression in Young and Middle-Aged Female Rats, with Modulation by Estradiol | Zendy

Jacqueline A. Maffucci | Zendy; Deena M. Walker | Zendy; Aiko Ikegami | Zendy; Michael J. Woller | Zendy; Andrea C. Gore | Zendy

Open Access

NMDA Receptor Subunit NR2b: Effects on LH Release and GnRH Gene Expression in Young and Middle-Aged Female Rats, with Modulation by Estradiol

Author(s) -

Jacqueline A. Maffucci,

Deena M. Walker,

Aiko Ikegami,

Michael J. Woller,

Andrea C. Gore

Publication year - 2007

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000111136

Subject(s) - ifenprodil , endocrinology , medicine , nmda receptor , gonadotropin releasing hormone , hypothalamus , glutamate receptor , gonadotropin , ovariectomized rat , biology , receptor , chemistry , luteinizing hormone , estrogen , hormone

The loss of reproductive capacity during aging involves changes in the neural regulation of the hypothalamic gonadotropin-releasing hormone (GnRH) neurons controlling reproduction. This neuronal circuitry includes glutamate receptors on GnRH neurons. Previously, we reported an increase in the expression of the NR2b subunit protein of the NMDA receptor on GnRH neurons in middle-aged compared to young female rats. Here, we examined the functional implications of the NR2b subunit on the onset of reproductive aging, using an NR2b-specific antagonist ifenprodil.

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