Neuregulin-1: A Potential Endogenous Protector in Perinatal Brain White Matter Damage | Zendy

Olaf Dammann | Zendy; Wolfgang Bueter | Zendy; Alan Leviton | Zendy; Pierre Gressèns | Zendy; Christiane E.L. Dammann | Zendy

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Neuregulin-1: A Potential Endogenous Protector in Perinatal Brain White Matter Damage

Author(s) -

Olaf Dammann,

Wolfgang Bueter,

Alan Leviton,

Pierre Gressèns,

Christiane E.L. Dammann

Publication year - 2007

Publication title -

neonatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.399

H-Index - 84

eISSN - 1661-7819

pISSN - 1661-7800

DOI - 10.1159/000111119

Subject(s) - neuregulin 1 , endogeny , brain damage , white matter , neuroscience , neuregulin , medicine , psychology , magnetic resonance imaging , receptor , radiology

Brain white matter damage, an important antecedent of long-term disabilities among preterm infants, has both endogenous and exogenous components. One of the endogenous components is the paucity of developmentally regulated protectors. Here we expand on this component, discussing the potential roles of one putative protector, neuregulin (NRG)-1, in brain development and damage. We outline how NRG-1 might be involved in perinatal brain damage pathomechanisms and suggest that NRG-1 might be one target for intervention.

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