E-Cadherin and Cell Adhesion: a Role in Architecture and Function in the Pancreatic Islet
Author(s) -
Gareth J. Rogers,
Matthew N. Hodgkin,
Paul E. Squires
Publication year - 2007
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000110459
Subject(s) - secretion , insulin , islet , microbiology and biotechnology , pancreatic islets , insulin oscillation , chemistry , cadherin , cell adhesion , cell , endocrinology , biology , medicine , biochemistry
The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of Langerhans. In this study, the role of ECAD in regulating insulin secretion from pseudoislets was investigated.
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