Cobalamin Potentiates Vinblastine Cytotoxicity Through Downregulation of mdr-1 Gene Expression in HepG2 Cells | Zendy

Véronique Marguerite | Zendy; Mylène BériDexheimer | Zendy; Sandrine Ortiou | Zendy; JeanLouis Guéant | Zendy; Marc Merten | Zendy

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Cobalamin Potentiates Vinblastine Cytotoxicity Through Downregulation of mdr-1 Gene Expression in HepG2 Cells

Author(s) -

Véronique Marguerite,

Mylène BériDexheimer,

Sandrine Ortiou,

JeanLouis Guéant,

Marc Merten

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000110457

Subject(s) - methylation , vinblastine , gene expression , biology , microbiology and biotechnology , multiple drug resistance , methionine , cytotoxicity , rhodamine 123 , cobalamin , pharmacology , biochemistry , cancer research , chemistry , gene , in vitro , chemotherapy , genetics , amino acid , antibiotics , vitamin b12

P-glycoprotein (Pgp), produced by multidrug resistance-1 gene (mdr-1), is a main mechanism developed by cancer cells to guard against anti-cancer drugs. Alterations of DNA methylation of the mdr-1 gene promoter are known to be linked to mdr-1 gene expression and are probably related to intracellular S-adenosyl-methionine. We here used HepG2 cells to determine the role of the methionine cycle (through the use of the Methionine-Synthase (MS) cofactor, cobalamin) on mdr-1 gene expression.

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