The Flavonoid Silibinin Decreases Glucose-6-Phosphate Hydrolysis in Perifused Rat Hepatocytes by an Inhibitory Effect on Glucose-6-Phosphatase | Zendy

Bruno Guigas | Zendy; Roula Naboulsi | Zendy; Gloria R. Villanueva | Zendy; Nellie Taleux | Zendy; José M. LópezNovoa | Zendy; Xavier Leverve | Zendy; MohamadYehia ElMir | Zendy

Open Access

The Flavonoid Silibinin Decreases Glucose-6-Phosphate Hydrolysis in Perifused Rat Hepatocytes by an Inhibitory Effect on Glucose-6-Phosphatase

Author(s) -

Bruno Guigas,

Roula Naboulsi,

Gloria R. Villanueva,

Nellie Taleux,

José M. LópezNovoa,

Xavier Leverve,

MohamadYehia ElMir

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000110453

Subject(s) - gluconeogenesis , silibinin , glycogenolysis , endocrinology , medicine , chemistry , biochemistry , glycogen , glucose 6 phosphatase , biology , metabolism , enzyme , pharmacology

The flavonoid silibinin has been reported to be beneficial in several hepatic disorders. Recent evidence also suggests that silibinin could be beneficial in the treatment of type 2 diabetes, owing to its anti-hyperglycemic properties. However, the mechanism(s) underlying these metabolic effects remains unknown.

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