Biosynthesis of Gastrokine-2 in the Human Gastric Mucosa: Restricted Spatial Expression along the Antral Gland Axis and Differential Interaction with TFF1, TFF2 and Mucins | Zendy

Irina Kouznetsova | Zendy; Werner Laubinger | Zendy; Hubert Kalbacher | Zendy; Thomas Kalinski | Zendy; Frank Meyer | Zendy; Albert Roessner | Zendy; Werner Hoffmann | Zendy

Open Access

Biosynthesis of Gastrokine-2 in the Human Gastric Mucosa: Restricted Spatial Expression along the Antral Gland Axis and Differential Interaction with TFF1, TFF2 and Mucins

Author(s) -

Irina Kouznetsova,

Werner Laubinger,

Hubert Kalbacher,

Thomas Kalinski,

Frank Meyer,

Albert Roessner,

Werner Hoffmann

Publication year - 2007

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000110450

Subject(s) - mucin , antrum , biology , laser capture microdissection , immunohistochemistry , microbiology and biotechnology , microdissection , gastric glands , mucus , gastric mucosa , gene expression , stomach , biochemistry , immunology , gene , ecology

Gastrokine-2 (GKN2) is a secretory peptide of human gastric surface mucous cells (SMCs). It forms disulfide-linked heterodimers with the trefoil factor family (TFF) peptide TFF1. Binding with TFF2 was also reported. Antral SMCs differ from those of the corpus by their TFF3 expression. The aim of this study was to localize GKN2 expression along the antral gland axis, to characterize the continuous regeneration of antral glands, and to investigate the interactions of GKN2 with TFF1, TFF2 and mucins.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research