Open AccessRole of Epidermal Growth Factor Receptor (EGFR)-Signaling Versus Cellular Acidosis Via Na<sup>+</sup>/H<sup>+</sup> Exchanger1(NHE1)-Inhibition in Troglitazone-Induced Growth Arrest of Breast Cancer-Derived Cells MCF-7
Author(s) -
Ellen Friday,
Robert Oliver,
Tomas Welbourne,
Francesco Turturro
Publication year - 2007
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000110435
Subject(s) - mapk/erk pathway , dna synthesis , epidermal growth factor , signal transduction , kinase , extracellular , epidermal growth factor receptor , acidosis , cell growth , microbiology and biotechnology , chemistry , biology , endocrinology , biochemistry , receptor , dna
We previously showed that troglitazone (TRO) induces a profound cellular acidosis in MCF-7 cells as a result of inhibiting Na(+)/H(+) exchanger (NHE)1-mediated acid extrusion and this was associated with a marked reduction in cellular proliferation. The present study focuses on TRO-activated signaling pathways versus TRO-mediated NHE1-inhibition in reducing DNA synthesis.
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