DNA Repair Polymorphisms Modify Bladder Cancer Risk: A Multi-factor Analytic Strategy | Zendy

Angeline S. Andrew | Zendy; Margaret R. Karagas | Zendy; Heather H. Nelson | Zendy; Simonetta Guarrera | Zendy; Silvia Polidoro | Zendy; Sara Gamberini | Zendy; Carlotta Sacerdote | Zendy; Jason H. Moore | Zendy; Karl T. Kelsey | Zendy; Eugene Demidenko | Zendy; Paolo Vineis | Zendy; Giuseppe Matullo | Zendy

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DNA Repair Polymorphisms Modify Bladder Cancer Risk: A Multi-factor Analytic Strategy

Author(s) -

Angeline S. Andrew,

Margaret R. Karagas,

Heather H. Nelson,

Simonetta Guarrera,

Silvia Polidoro,

Sara Gamberini,

Carlotta Sacerdote,

Jason H. Moore,

Karl T. Kelsey,

Eugene Demidenko,

Paolo Vineis,

Giuseppe Matullo

Publication year - 2007

Publication title -

human heredity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.423

H-Index - 62

eISSN - 1423-0062

pISSN - 0001-5652

DOI - 10.1159/000108942

Subject(s) - xrcc3 , xrcc1 , single nucleotide polymorphism , genotype , biology , odds ratio , genetics , multifactor dimensionality reduction , gene , medicine

A number of common non-synonymous single nucleotide polymorphisms (SNPs) in DNA repair genes have been reported to modify bladder cancer risk. These include: APE1-Asn148Gln, XRCC1-Arg399Gln and XRCC1-Arg194Trp in the BER pathway, XPD-Gln751Lys in the NER pathway and XRCC3-Thr241Met in the DSB repair pathway.

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