Combined Effects of Carbonic Anhydrase Inhibitor and Adenosine A1 Receptor Antagonist on Hemodynamic and Tubular Function in the Kidney | Zendy

Cynthia M. Miracle | Zendy; Timo Rieg | Zendy; Roland C. Blantz | Zendy; Volker Vallon | Zendy; Scott C. Thomson | Zendy

Open Access

Combined Effects of Carbonic Anhydrase Inhibitor and Adenosine A₁ Receptor Antagonist on Hemodynamic and Tubular Function in the Kidney

Author(s) -

Cynthia M. Miracle,

Timo Rieg,

Roland C. Blantz,

Volker Vallon,

Scott C. Thomson

Publication year - 2007

Publication title -

kidney and blood pressure research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.806

H-Index - 51

eISSN - 1423-0143

pISSN - 1420-4096

DOI - 10.1159/000108625

Subject(s) - tubuloglomerular feedback , reabsorption , chemistry , macula densa , endocrinology , medicine , nephron , renal physiology , natriuresis , renal sodium reabsorption , adenosine , tubular fluid , renal function , excretion , kidney , acetazolamide , biochemistry , biology , renin–angiotensin system , blood pressure

Carbonic anhydrase inhibitors (CAI) reduce proximal reabsorption, activating tubuloglomerular feedback (TGF) and reducing glomerular filtration rate (GFR). Adenosine A(1) receptors (A(1)R) mediate the TGF response and stimulate proximal reabsorption.

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